Expression of Tropomyosin 2 Gene Isoforms in Human cardiac Tissue

Expression of Tropomyosin 2 Gene Isoforms in Human Cardiac Tissue

Previous studies have shown that although the transcript levels of TPM1α and TPM1k are expressed in human hearts in comparable levels, the level of TPM1α protein is ~90%. The proteins of TPM1κ and TPM2α are about 5% of the total sarcomeric TM. 

Cardiac Tissue

The TPM2gene is known to generate three alternatively spliced isoforms, which are designated as TPM2α, TPM2β, and TPM2γ. The expression level of TPM2β and TPM2γ in human hearts is unknown.

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