Most systemic chemo therapic agents used in lung cancer treatment can lead to hypersensitivity reactions, of varying degrees of severity. In
absence of laboratory tests (such as elevated serum total tryptase or/and plasma histamine levels).Distinguishing
between anaphylaxis and acute infusion reactions is impossible since their symptoms are identical.
Few Paclitaxel hypersensitivity reactions described in literature are documented in the absence of standardized tests to chemotherapeutics
drugs and since not all suspected patients undergo allergological tests. A 74 years old female patient, with history of Inobitriol induced laryngeal
angioedema and right middle lobe NSCLC, developed a moderate anaphylactic reaction during Paclitaxel second administration. Infusion
suspension and symptomatic treatments led to rapid symptoms remission. Prick tests to Paclitaxel were negatives but the intradermal reaction
was positive, as well as basophile activation test.
